Assessing the clinical significance of botanical supplementation on human cytochrome P450 3A activity: comparison of a milk thistle and black cohosh product to rifampin and clarithromycin
Gurley B, Hubbard MA, Williams DK, Thaden J
Published in Journal of Clinical Pharmacology
Methodology
Randomized supplementation trial in healthy volunteers; milk thistle 900 mg or black cohosh 80 mg for 14 days with rifampin and clarithromycin positive controls; oral midazolam probe pharmacokinetics
Key Findings
Midazolam pharmacokinetics were unaffected by milk thistle or black cohosh, while rifampin and clarithromycin produced the expected induction and inhibition.
Conclusions
Milk thistle and black cohosh appear to have no clinically relevant effect on phase I CYP3A activity in vivo.
Limitations
Healthy volunteers, single probe drug, standardized products may not represent all commercial preparations.
Supplements Studied
Milk thistle and black cohosh appear to have no clinically relevant effect on CYP3A activity in vivo.
Milk thistle and black cohosh appear to have no clinically relevant effect on CYP3A activity in vivo.
Outcomes Measured
Milk thistle and black cohosh appear to have no clinically relevant effect on CYP3A activity in vivo.
Study Details
Access Study
Disclosures
Funding
NIH
This information is for educational purposes only. Always consult a healthcare professional before starting any supplement regimen.