Comparing the effects of yogurt containing Akkermansia muciniphila postbiotic with yogurt containing Lactobacillus rhamnosus postbiotic on body composition, biochemical indices, appetite, and depression scores in overweight or obese adults
Aalipanah E, Askarpour M, Eskandari MH, Zare M, Famouri M, Bedeltavana A, Mohsenpour MA, Sohrabi Z
Published in Clinical Nutrition ESPEN
Methodology
Eight-week randomized, double-blind, three-arm controlled trial comparing A. muciniphila postbiotic-fortified yogurt, L. rhamnosus postbiotic yogurt and low-fat yogurt placebo in adults with overweight or obesity (IRCT20230522058257N1).
Key Findings
The Akkermansia postbiotic yogurt group showed significant reductions in waist circumference (P = 0.003), waist-to-height ratio (P = 0.004), body fat percentage (P = 0.032), aspartate aminotransferase (P = 0.045) and appetite scores (P = 0.047) versus control, while the L. rhamnosus yogurt showed no benefit.
Conclusions
Yogurt enriched with A. muciniphila postbiotic may favorably affect weight management and liver enzymes, though confirmation is needed.
Limitations
Small groups (n = 22 each), short duration, postbiotic dairy matrix rather than a capsule supplement, single centre.
Supplements Studied
In the AMY group, significant reductions were observed in waist circumference, waist-to-height ratio, body fat percentage, aspartate aminotransferase levels, and appetite scores compared with the control group.
Study Details
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Disclosures
Funding
Academic with dairy-industry collaboration (Zarrin Ghazal Company)
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