Effect of multivitamin-mineral supplementation versus placebo on cognitive function: results from the clinic subcohort of COSMOS and meta-analysis of 3 cognitive studies
Vyas CM, Manson JE, Sesso HD
Published in The American Journal of Clinical Nutrition
Methodology
Randomised placebo-controlled COSMOS-Clinic subcohort (573 adults aged 60+) with detailed neuropsychological testing, plus meta-analysis across three COSMOS cognitive substudies
Key Findings
A modest benefit of multivitamin-mineral on global cognition over 2 years with a significantly more favourable change in episodic memory
Conclusions
Daily multivitamin-mineral use produces small cognitive benefits in older adults, largest for memory rather than executive domains
Limitations
Effect sizes small; largely well-nourished participants
Supplements Studied
we observed a modest benefit of MVM compared with placebo on global cognition over 2 y
Outcomes Measured
we observed a modest benefit of MVM compared with placebo on global cognition over 2 y {mean difference [95% confidence interval (CI)] = 0.06 SD units (SU) (-0.003, 0.13)}, with a significantly more favorable change in episodic memory
A modest benefit of multivitamin-mineral on global cognition over 2 years with a significantly more favourable change in episodic memory
Study Details
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