The effect of probiotics on functional constipation in adults: a systematic review and meta-analysis of randomized controlled trials
Dimidi E, Christodoulides S, Fragkos KC, Scott SM, Whelan K
Published in American Journal of Clinical Nutrition
Methodology
Systematic review and meta-analysis of 14 randomized controlled trials of probiotics in adults with functional constipation
Key Findings
Probiotics reduced whole-gut transit time by 12.4 hours (95% CI -22.3 to -2.5), increased stool frequency by 1.3 bowel movements per week and improved stool consistency; effects were driven mainly by Bifidobacterium lactis strains.
Conclusions
Probiotics, particularly B. lactis, produce modest improvements in constipation symptoms, but strain-level evidence is limited.
Limitations
Small heterogeneous trials, short durations, high risk of bias in several studies, many industry funded.
Supplements Studied
Probiotics reduced whole gut transit time, increased stool frequency, and improved stool consistency in adults with functional constipation.
Outcomes Measured
Probiotics reduced whole-gut transit time by 12.4 hours (95% CI -22.3 to -2.5), increased stool frequency by 1.3 bowel movements per week and improved stool consistency; effects were driven mainly by Bifidobacterium lactis strains.
Probiotics significantly reduced whole gut transit time by 12.4 h and increased stool frequency by 1.3 bowel movements/wk.
Related Health Concerns
Study Details
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Disclosures
Funding
Academic; some authors received research funding from food companies
This information is for educational purposes only. Always consult a healthcare professional before starting any supplement regimen.