Effects of spermidine supplementation on cognition and biomarkers in older adults with subjective cognitive decline: a randomized clinical trial
Schwarz C, Benson GS, Horn N, Wurdack K, Grittner U, Schilling R, Wirth M, Floel A
Published in JAMA Network Open
Methodology
Twelve-month randomized, double-blind, placebo-controlled trial (SmartAge) of spermidine-rich wheat germ extract in 100 older adults with subjective cognitive decline.
Key Findings
No significant difference in memory performance or secondary cognitive and biomarker outcomes between spermidine and placebo.
Conclusions
Longer-term spermidine supplementation did not improve memory in older adults with subjective cognitive decline.
Limitations
Single-centre; one dose and formulation; possible ceiling effects in a high-functioning sample.
Supplements Studied
Longer-term spermidine supplementation did not improve memory in older adults with subjective cognitive decline.
Outcomes Measured
Longer-term spermidine supplementation did not improve memory in older adults with subjective cognitive decline.
Related Health Concerns
Study Details
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