Exploring the Impact of Hydrolyzed Collagen Oral Supplementation on Skin Rejuvenation: A Systematic Review and Meta-Analysis

Dewi DAR

Published in Cureus

Methodology

Systematic review and meta-analysis of randomised, double-blind, controlled trials of oral hydrolysed collagen published 2017-2023 in CENTRAL, PubMed, Google Scholar and ScienceDirect, reporting outcomes for skin aging, wrinkles, moisture, elasticity and firmness; 14 studies with 967 participants pooled.

Key Findings

This meta-analysis pooled 14 randomised, double-blind controlled trials published 2017-2023 with 967 participants taking oral hydrolysed collagen. Compared with placebo, collagen produced substantial improvements in skin moisture and elasticity, consistently supported in subgroup analysis. The authors conclude a 12-week regimen of hydrolysed collagen improves skin hydration and elasticity.

Conclusions

Hydrolyzed collagen consistently improved skin moisture and elasticity, though pooled trials were heterogeneous.

Limitations

The abstract reports no effect sizes or confidence intervals for the pooled results, the trials are typically industry-funded and short at around 12 weeks, and the journal is a low-barrier publication venue.