systematic_review
    2009
    High Quality

    S-Adenosylmethionine for osteoarthritis of the knee or hip

    Rutjes AWS, Nuesch E, Reichenbach S

    Published in Cochrane Database of Systematic Reviews

    Key Findings

    Current evidence was inconclusive; effects on pain and function were small and potentially due to bias in low-quality trials.

    Conclusions

    No reliable benefit demonstrated for osteoarthritis.

    Limitations

    Small, poorly reported trials.

    Supplements Studied

    L-Methionine
    Amino Acid

    Current evidence on S-adenosylmethionine for osteoarthritis is inconclusive and effects may be due to bias.

    SAM-e
    Compound

    S-Adenosylmethionine may be a viable treatment option but the evidence about its effectiveness and safety is equivocal.

    Outcomes Measured

    Joint Comfort

    Evidence on SAMe for osteoarthritis pain and function is equivocal.

    Related Health Concerns

    Osteoarthritis

    Study Details

    Year:2009
    Sample Size:656
    Quality Score:9/10

    Access Study

    View on DOIView on PubMedOriginal Source

    This information is for educational purposes only. Always consult a healthcare professional before starting any supplement regimen.