Demonstration of rapid onset vascular endothelial dysfunction after hyperhomocysteinemia: an effect reversible with vitamin C therapy
Chambers JC, McGregor A, Jean-Marie J
Published in Circulation
Key Findings
Oral methionine loading raised homocysteine and acutely impaired flow-mediated endothelial function in healthy men.
Conclusions
Acute high-dose methionine is vasotoxic via homocysteine.
Limitations
Acute loading dose, surrogate endpoint.
Supplements Studied
Oral methionine loading raised homocysteine and acutely impaired flow-mediated endothelial function.
Oral methionine loading raised homocysteine and acutely impaired flow-mediated endothelial function in healthy men.
Outcomes Measured
Acute methionine loading raised homocysteine, which impaired endothelial function relevant to vascular cognitive risk.
Oral methionine loading raised homocysteine and acutely impaired flow-mediated endothelial function in healthy men.
Study Details
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