High-Dose Thiamine Supplementation in Older Patients With Heart Failure: A Pilot Randomized Controlled Crossover Trial (THIAMINE-HF)
Smith TR, Lee JY, Leong DP, et al.
Published in CJC Open
Abstract
Pilot randomized double-blind placebo-controlled crossover trial of high-dose thiamine in older adults with heart failure.
Key Findings
High-dose thiamine did not improve the primary endpoint of 6-minute walk distance compared with placebo in older heart failure patients.
Conclusions
This well-designed pilot crossover RCT was null for functional capacity, tempering enthusiasm from earlier surrogate-endpoint trials.
Limitations
Pilot sample size, crossover design, short treatment periods.
Supplements Studied
High-dose thiamine did not improve the primary endpoint of 6-minute walk distance compared with placebo in older heart failure patients.
Related Health Concerns
Study Details
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