Saffron (Crocus sativus) for depression: a systematic review of clinical studies and examination of underlying antidepressant mechanisms of action

Lopresti AL, Drummond PD

Published in Human Psychopharmacology

Key Findings

Clinical studies consistently favour saffron over placebo, with proposed serotonergic, anti-inflammatory and neuroprotective mechanisms.

Promising but the evidence base needs independent replication outside Iran.

Reviewed trials share investigators and funding sources.

Herb

Clinical studies consistently favour saffron over placebo, with proposed serotonergic, anti-inflammatory and neuroprotective mechanisms.

Year:2014

Quality Score:6/10

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