Occurrence of D-aspartic acid in human seminal plasma and spermatozoa: possible role in reproduction
D'Aniello G, Ronsini S, Guida F, Spinelli P, D'Aniello A
Published in Fertility and Sterility
Methodology
Prospective observational comparison of D-aspartic acid concentrations in seminal plasma and spermatozoa across normospermic, oligoasthenoteratospermic and azoospermic men using enzymatic HPLC and immunohistochemistry
Key Findings
D-aspartic acid concentrations in seminal plasma and spermatozoa were significantly lower in men with impaired sperm quality.
Conclusions
Endogenous D-aspartic acid is associated with sperm quality, which motivates but does not validate supplementation.
Limitations
Small observational sample; association only; no supplementation arm.
Supplements Studied
The concentration of D-Asp in seminal plasma and in spermatozoa was significantly reduced in oligoasthenoteratospermic donors.
Study Details
Access Study
Disclosures
Funding
Not reported
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