Bisphosphonates for steroid-induced osteoporosis
Allen CS, Yeung JH, Vandermeer B
Published in Cochrane Database of Systematic Reviews
Methodology
Cochrane review of 27 randomized trials of bisphosphonates in glucocorticoid-treated patients, with calcium and vitamin D co-therapy.
Key Findings
Bisphosphonates increased lumbar spine bone density and reduced vertebral fractures versus calcium with or without vitamin D alone.
Conclusions
Bisphosphonates plus calcium and vitamin D protect bone during glucocorticoid excess.
Limitations
Moderate certainty; fracture data limited to vertebral sites.
Supplements Studied
Bisphosphonates, with calcium and vitamin D, increase bone mineral density and reduce vertebral fractures in patients receiving glucocorticoids.
Bisphosphonates, with calcium and vitamin D, increase bone mineral density and reduce vertebral fractures in patients receiving glucocorticoids.
Related Health Concerns
Study Details
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