New Insight into the Role of Vitamin D in the Stroke Risk: A Meta-Analysis of Stratified Data by 25(OH)D Levels
Fusaro M, De Caterina R, Tripepi G
Published in Current Vascular Pharmacology
Methodology
Review of weak-instrument bias in Mendelian randomization plus an original meta-analysis of aggregated data stratified by population mean 25(OH)D levels.
Key Findings
Stratified meta-analysis indicated that any benefit of vitamin D interventions on stroke is confined to populations with low mean 25(OH)D levels; no signal in replete populations.
Conclusions
Vitamin D repletion may matter only where deficiency is prevalent; causal inference is limited by weak genetic instruments.
Limitations
Aggregated rather than individual-level data; Mendelian randomization instruments explain little exposure variance.
Supplements Studied
an original meta-analysis stratified by population mean levels of 25(OH)D
Related Health Concerns
Study Details
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Disclosures
Funding
Not reported
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