Vitamin K supplementation and progression of coronary artery calcium in older men and women
Shea MK, O'Donnell CJ, Hoffmann U, Dallal GE, Dawson-Hughes B, Ordovas JM, Price PA, Williamson MK, Booth SL
Published in American Journal of Clinical Nutrition
Methodology
Three-year randomised trial of phylloquinone 500 mcg/day versus control on coronary artery calcium progression in 388 older adults.
Key Findings
No difference in overall calcium progression, though a per-protocol analysis of adherent participants showed less progression among those with pre-existing calcification.
Conclusions
Vitamin K1 did not slow coronary calcification in the intention-to-treat analysis.
Limitations
Per-protocol findings vulnerable to adherence confounding; single dose tested.
Supplements Studied
Vitamin K1 did not slow coronary artery calcium progression in the intention-to-treat analysis.
No difference in overall calcium progression, though a per-protocol analysis of adherent participants showed less progression among those with pre-existing calcification.
Related Health Concerns
Study Details
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This information is for educational purposes only. Always consult a healthcare professional before starting any supplement regimen.