systematic_review
    2017
    High Quality

    The mechanisms of action of metformin

    Unknown authors

    Published in Diabetologia

    Key Findings

    Metformin inhibits mitochondrial complex I and raises the AMP:ATP ratio, activating AMPK-dependent and independent pathways.

    Conclusions

    Reference pharmacologic model of AMPK activation.

    Outcomes Measured

    AMPK Activation
    Primary

    Metformin inhibits mitochondrial complex I and raises the AMP:ATP ratio, activating AMPK-dependent and independent pathways.

    Study Details

    Year:2017
    Quality Score:8/10

    Access Study

    View on DOIView on PubMedOriginal Source

    This information is for educational purposes only. Always consult a healthcare professional before starting any supplement regimen.