Dose-dependent detoxication of the airborne pollutant benzene in a randomized trial of broccoli sprout beverage in Qidong, China
Chen JG, Johnson J, Egner P, Ng D
Published in The American Journal of Clinical Nutrition
Methodology
Randomized, placebo-controlled multidose trial of broccoli sprout beverage (full, one-half, one-fifth concentration) for 10 consecutive days; urinary S-phenylmercapturic acid measured by mass spectrometry
Key Findings
Broccoli sprout beverage increased excretion of the benzene detoxication biomarker S-phenylmercapturic acid in a dose-dependent manner versus placebo.
Conclusions
Sulforaphane-yielding broccoli sprout beverages enhance conjugative detoxication of an airborne carcinogen at practical doses.
Limitations
Short 10-day exposure, single geographic population with high pollutant exposure, biomarker rather than clinical endpoints.
Supplements Studied
Concentrations of SPMA arising through induced benzene conjugation with glutathione were quantified by MS in sequential 12-h overnight urine collections
Outcomes Measured
A randomized, placebo-controlled, multidose trial of a broccoli sprout beverage was designed to determine the lowest effective concentration that enhances benzene detoxication adjudged by enhanced excretion of the urinary biomarker, S-phenylmercapturic acid (SPMA).
Study Details
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Disclosures
Funding
NIH
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