Boron and bone health: a systematic review
Hunt, C.D.
Published in Journal of Trace Elements in Medicine
Abstract
Systematic review of boron effects on bone metabolism and osteoporosis prevention
Methodology
Systematic review of experimental animal studies and human depletion-repletion and observational studies examining boron intake and markers of bone and mineral metabolism.
Key Findings
This review of human and animal data found boron influences calcium, magnesium and vitamin D metabolism and steroid hormone levels, with depletion-repletion studies suggesting boron may reduce urinary calcium loss, but no clinical trials demonstrating reduced fracture risk or improved bone mineral density in humans.
Conclusions
Boron plausibly supports bone-related mineral and hormone metabolism, yet clinical evidence that supplementation improves bone health outcomes is absent.
Limitations
Narrative/systematic review dominated by small depletion-repletion studies and animal models, no adequately powered randomised trials, inconsistent dosing, and no fracture or bone density endpoints.
Supplements Studied
This review of human and animal data found boron influences calcium, magnesium and vitamin D metabolism and steroid hormone levels, with depletion-repletion studies suggesting boron may reduce urinary calcium loss, but no clinical trials demonstrating reduced fracture risk or improved bone mineral density in humans.
This review of human and animal data found boron influences calcium, magnesium and vitamin D metabolism and steroid hormone levels, with depletion-repletion studies suggesting boron may reduce urinary calcium loss, but no clinical trials demonstrating reduced fracture risk or improved bone mineral density in humans.
This review of human and animal data found boron influences calcium, magnesium and vitamin D metabolism and steroid hormone levels, with depletion-repletion studies suggesting boron may reduce urinary calcium loss, but no clinical trials demonstrating reduced fracture risk or improved bone mineral density in humans.
This review of human and animal data found boron influences calcium, magnesium and vitamin D metabolism and steroid hormone levels, with depletion-repletion studies suggesting boron may reduce urinary calcium loss, but no clinical trials demonstrating reduced fracture risk or improved bone mineral density in humans.
Outcomes Measured
This review of human and animal data found boron influences calcium, magnesium and vitamin D metabolism and steroid hormone levels, with depletion-repletion studies suggesting boron may reduce urinary calcium loss, but no clinical trials demonstrating reduced fracture risk or improved bone mineral density in humans.
Study Details
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Disclosures
Funding
US Department of Agriculture Agricultural Research Service
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