Clinically Insignificant Effect of Supplemental Vitamin C on Serum Urate in Patients With Gout: A Pilot Randomized Controlled Trial
Stamp LK, Frampton C, O Donnell JL, Drake J, Chapman PT
Published in Arthritis and Rheumatism
Methodology
Randomized double-blind placebo-controlled pilot trial of vitamin C alone or added to allopurinol in gout patients with serum urate above 0.36 mmol/L
Key Findings
Vitamin C produced only a small, clinically insignificant reduction in serum urate whether given alone or added to allopurinol
Conclusions
Vitamin C is not an effective urate-lowering therapy in established gout
Limitations
Small pilot sample limits power; short duration
Supplements Studied
Studies in human volunteers have shown that vitamin C reduces serum urate (SU) levels. The aim of this study was to determine the effects of vitamin C on SU levels in patients with gout.
Related Health Concerns
Study Details
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