Short-Term Magnesium Therapy Alleviates Moderate Stress in Patients with Fibromyalgia: A Randomized Double-Blind Clinical Trial

Macian N

Published in Nutrients

Methodology

Randomised, double-blind, placebo-controlled trial of oral magnesium for 1 month in fibromyalgia patients, with perceived stress scale, fibromyalgia impact questionnaire, pain and quality-of-life endpoints.

Key Findings

In 78 patients with fibromyalgia, one month of oral magnesium supplementation reduced perceived stress and improved some quality-of-life and fibromyalgia impact measures compared with placebo, with the effect most evident in patients with moderate baseline stress; pain intensity itself changed little.

Conclusions

Short-term magnesium supplementation eased stress and overall impact in fibromyalgia patients with moderate stress, but did not meaningfully reduce pain.

Limitations

Small sample, only 4 weeks of treatment with no follow-up, subgroup-specific benefit identified within a modest trial, self-reported stress and impact outcomes, and baseline magnesium status not uniformly deficient.