Analgesic efficacy of collagen peptide in knee osteoarthritis: a meta-analysis of randomized controlled trials
Lin CR, Tsai SHL, Huang KY, Tsai PA, Chou H
Published in Journal of Orthopaedic Surgery and Research
Methodology
PRISMA systematic review and meta-analysis of four randomized controlled trials in 507 knee osteoarthritis patients comparing collagen peptides or hydrolyzed collagen with control, appraised with Cochrane ROB 2.0 and GRADE
Key Findings
Collagen peptides produced modest analgesic benefit in knee osteoarthritis with a favourable safety profile, but the certainty of evidence was limited.
Conclusions
Collagen peptides are a low-risk adjunct with modest, low-certainty pain benefit.
Limitations
Only four trials; 507 participants; varying collagen types and doses; low GRADE certainty.
Supplements Studied
Four trials involving 507 patients with knee osteoarthriti
Related Health Concerns
Study Details
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Disclosures
Funding
Not reported
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