Vitamin D supplementation to prevent acute respiratory tract infections: systematic review and meta-analysis of individual participant data
Martineau AR, Jolliffe DA, Hooper RL, Greenberg L, Aloia JF, Bergman P
Published in BMJ
Methodology
Individual participant data meta-analysis of 25 randomized controlled trials of vitamin D supplementation for respiratory infection prevention.
Key Findings
Vitamin D reduced acute respiratory infection risk overall, with the largest benefit in profoundly deficient participants receiving daily or weekly dosing.
Conclusions
Correcting vitamin D deficiency improves defence against respiratory pathogens.
Limitations
Bolus dosing showed no benefit; heterogeneity across trials.
Supplements Studied
Vitamin D reduced acute respiratory infection risk overall, with the largest benefit in deficient participants
Outcomes Measured
Vitamin D reduced acute respiratory infection risk overall, with the largest benefit in profoundly deficient participants
Vitamin D reduced acute respiratory infection risk overall, with the largest benefit in profoundly deficient participants
Vitamin D reduced acute respiratory infection risk overall, with the largest benefit in profoundly deficient participants
Vitamin D supplementation reduced the risk of acute respiratory tract infection, with the greatest effect in the most deficient.
Vitamin D supplementation reduced acute respiratory infection risk, most clearly among those with low baseline vitamin D status.
Vitamin D supplementation reduced the risk of acute respiratory tract infection, with the greatest benefit in deficient individuals.
Related Health Concerns
Study Details
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This information is for educational purposes only. Always consult a healthcare professional before starting any supplement regimen.