rct
    2017
    High Quality

    Colorectal adenomas in participants of the SELECT randomized trial of selenium and vitamin E

    Lance P, Alberts DS, Thompson PA, Fales L, Wang F

    Published in Cancer Prevention Research

    Methodology

    Ancillary analysis of colorectal adenoma occurrence among SELECT participants undergoing lower endoscopy, comparing selenomethionine and alpha-tocopherol with placebo

    Key Findings

    Neither selenium nor vitamin E supplementation reduced colorectal adenoma occurrence relative to placebo

    Conclusions

    Selenium and vitamin E do not prevent colorectal neoplasia

    Limitations

    Non-randomized endoscopy subset, men only, adenoma surrogate endpoint

    Supplements Studied

    Vitamin E
    Vitamin

    the effect of vitamin E (as α-tocopherol) supplementation on colorectal adenoma occurrence considered as a secondary objective

    Selenium
    Mineral

    The primary objective was to measure the effect of selenium (as selenomethionine) on colorectal adenomas occurrence

    Related Health Concerns

    Colorectal Cancer

    Study Details

    Year:2017
    Sample Size:6,546
    Quality Score:8/10

    Access Study

    View on DOIView on PubMedOriginal Source

    Disclosures

    Funding

    National Cancer Institute

    This information is for educational purposes only. Always consult a healthcare professional before starting any supplement regimen.