Magnesium and Cardiovascular Disease
DiNicolantonio JJ, Liu J, O'Keefe JH
Published in Open Heart
Abstract
Review examining magnesium role in cardiovascular health, including effects on blood pressure, arrhythmias, and heart disease prevention.
Methodology
Narrative review of mechanistic, epidemiological and clinical literature on magnesium status and cardiovascular outcomes.
Key Findings
Review evidence links subclinical magnesium deficiency to hypertension, arrhythmias, arterial calcification, endothelial dysfunction and increased cardiovascular mortality, and argues that serum magnesium is an insensitive marker that hides widespread inadequacy.
Conclusions
The authors position chronic low magnesium intake as an under-recognised contributor to cardiovascular disease and call for better assessment and higher dietary intake.
Limitations
Narrative review with selective citation and a strong prior position; observational associations dominate, and interventional evidence for hard cardiovascular endpoints remains limited.
Supplements Studied
Review evidence links subclinical magnesium deficiency to hypertension, arrhythmias, arterial calcification, endothelial dysfunction and increased cardiovascular mortality, and argues that serum magnesium is an insensitive marker that hides widespread inadequacy.
Related Health Concerns
Study Details
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Disclosures
Funding
No specific funding reported; one author has commercial interests in nutritional supplements
This information is for educational purposes only. Always consult a healthcare professional before starting any supplement regimen.