Role of probiotics in chronic rhinosinusitis: a systematic review of randomised, controlled trials
Fong P, Lim K, Gnanam A, Charn T
Published in The Journal of Laryngology and Otology
Methodology
Systematic review of four randomised controlled trials of adjunctive probiotics in adults with chronic rhinosinusitis
Key Findings
No reduction in Sino-Nasal Outcome Test scores before 4 weeks or beyond 8 weeks, but symptom relapse was significantly lower with probiotics (RR 0.49 during treatment; 0.56 at 8 months)
Conclusions
Probiotics do not improve core symptom scores but may reduce relapse; optimal strain and duration unknown
Limitations
Only four heterogeneous trials, different strains and doses, small samples
Supplements Studied
Lower sinusitis relapse risks during treatment (risk ratio = 0.49; p = 0.019) and 8 months post-treatment (risk ratio = 0.56, p = 0.013) were observed.
Related Health Concerns
Study Details
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