Gallstone Dissolution Effects of Combination Therapy with n-3 Polyunsaturated Fatty Acids and Ursodeoxycholic Acid: A Randomized, Prospective, Preliminary Clinical Trial
Lee SY, Jang SI, Cho JH, Do MY, Lee DK
Published in Gut and Liver
Methodology
Randomized prospective preliminary trial of n-3 polyunsaturated fatty acids plus ursodeoxycholic acid versus UDCA alone for cholesterol gallstone dissolution with imaging follow-up
Key Findings
Combination of n-3 PUFA with UDCA showed potential for improved gallstone dissolution compared with UDCA monotherapy
Conclusions
Adding n-3 PUFA to UDCA may enhance cholesterol gallstone dissolution; larger trials needed
Limitations
Small pilot sample; exploratory design; short follow-up
Supplements Studied
Combination of n-3 polyunsaturated fatty acids with ursodeoxycholic acid showed potential for improved gallstone dissolution compared with UDCA monotherapy.
Related Health Concerns
Study Details
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Disclosures
Funding
Yonsei University Health System
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