Impact of folic acid supplementation on the epigenetic profile in healthy unfortified individuals - a randomized intervention trial
Michels KB, Binder AM
Published in Epigenetics
Methodology
Randomised intervention trial of 400 ug folic acid daily versus control in 16 healthy male volunteers from an unfortified population
Key Findings
Folic acid supplementation produced only limited and site-specific changes in the DNA methylation profile
Conclusions
Methyl-donor supply alone does not reliably remodel the methylome in healthy adults
Limitations
Very small all-male sample
Supplements Studied
We conducted a randomized intervention trial to test the influence of folic acid supplementation on DNA methylation in an unfortified population in Germany.
Outcomes Measured
We conducted a randomized intervention trial to test the influence of folic acid supplementation on DNA methylation in an unfortified population in Germany.
Study Details
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