rct
    2020
    High Quality

    Intake of Camelina Sativa Oil and Fatty Fish Alter the Plasma Lipid Mediator Profile in Subjects with Impaired Glucose Metabolism - A Randomized Controlled Trial

    Meuronen T, Lankinen MA, Fauland A, Shimizu BI, de Mello VD

    Published in Prostaglandins, Leukotrienes and Essential Fatty Acids

    Methodology

    Secondary analysis of a 12-week randomized controlled dietary intervention in 79 subjects with impaired fasting glucose (camelina oil n=18, fatty fish n=20, lean fish n=21, control n=20); plasma lipid mediators profiled by LC-MS/MS.

    Key Findings

    ALA-derived lipid mediators increased and the arachidonic-acid-derived 5-iso prostaglandin F2a-VI decreased in the camelina oil group, while fatty fish raised EPA/DHA-derived mediators.

    Conclusions

    Camelina oil shifts the circulating lipid-mediator profile toward ALA-derived species, a plausible anti-inflammatory mechanism.

    Limitations

    Mechanistic biomarker outcomes only, small per-arm numbers, no clinical inflammatory endpoints.

    Supplements Studied

    Concentrations of lipid mediators derived from alpha-linolenic acid (ALA) increased and arachidonic acid (AA) derived 5-iso prostaglandin F2alpha-VI decreased in the CSO group.

    Outcomes Measured

    Concentrations of lipid mediators derived from alpha-linolenic acid (ALA) increased and arachidonic acid (AA) derived 5-iso prostaglandin F2alpha-VI decreased in the CSO group.

    Related Health Concerns

    Study Details

    Year:2020
    Sample Size:79
    Duration:12 weeks
    Quality Score:7/10

    Disclosures

    Funding

    Academic funding

    This information is for educational purposes only. Always consult a healthcare professional before starting any supplement regimen.