Effectiveness of Omega-3 Polyunsaturated Fatty Acids in Non-alcoholic Fatty Liver Disease: A Systematic Review and Meta-Analysis
Aziz T, Niraj MK, Kumar S, Kumar R
Published in Cureus
Methodology
Systematic review and meta-analysis of 15 studies (2018-2023) of omega-3 polyunsaturated fatty acids in NAFLD, assessing liver fat, hepatic enzymes and lipids.
Key Findings
Omega-3 significantly reduced ALT (MD -2.12, 95% CI -3.36 to -0.87) and AST (MD -1.50, 95% CI -2.59 to -0.42), with GGT showing only a trend.
Conclusions
Omega-3 modestly improves liver enzymes in NAFLD; effects on histology are unproven.
Limitations
Small enzyme changes of uncertain clinical relevance; mixed study designs including animal data.
Supplements Studied
Omega-3 supplementation significantly decreased alanine aminotransferase (ALT) (mean difference = -2.12, 95% confidence interval (CI) = -3.36, -0.87) and aspartate aminotransferase (AST) (mean difference = -1.50, 95% CI = -2.59, -0.42).
Related Health Concerns
Study Details
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Disclosures
Funding
Not reported
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