Melatonin for the prevention and treatment of jet lag
Herxheimer A, Petrie KJ
Published in Cochrane Database of Systematic Reviews
Methodology
Cochrane systematic review and meta-analysis of randomised trials of oral melatonin taken close to target bedtime for jet lag after crossing multiple time zones.
Key Findings
Melatonin taken close to target bedtime at destination decreased jet lag from flights crossing five or more time zones, with doses of 0.5-5 mg similarly effective though higher doses induced sleep faster.
Conclusions
Melatonin is remarkably effective for preventing or reducing jet lag; occasional use appears safe.
Limitations
Older review; small trials with subjective outcome measures; limited safety data in people with epilepsy or on warfarin.
Supplements Studied
Melatonin taken close to target bedtime decreased jet lag from flights crossing five or more time zones.
Outcomes Measured
Melatonin taken close to target bedtime decreased jet lag after crossing five or more time zones.
Melatonin for the prevention and treatment of jet lag
Study Details
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Disclosures
Funding
Cochrane Collaboration
This information is for educational purposes only. Always consult a healthcare professional before starting any supplement regimen.