5-Hydroxytryptophan for depression: a systematic review of clinical trials
Shaw K, Turner J, Del Mar C
Published in Cochrane Database of Systematic Reviews
Methodology
Cochrane review of randomised trials of 5-hydroxytryptophan and tryptophan versus placebo for depressive disorders.
Key Findings
Only two of 108 identified trials were of adequate quality; these showed a benefit over placebo but the evidence was too weak to recommend routine use.
Conclusions
5-HTP's serotonergic mood benefit is suggested but poorly evidenced.
Limitations
Nearly all trials excluded for poor quality; safety concerns historically.
Supplements Studied
Only two of 108 identified trials were of adequate quality; the evidence was too weak to recommend routine use
Outcomes Measured
Only two of 108 identified trials were of adequate quality; these showed a benefit over placebo but the evidence was too weak to recommend routine use
Related Health Concerns
Study Details
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