The Effect of Nicotinamide Mononucleotide and Riboside on Skeletal Muscle Mass and Function: A Systematic Review and Meta-Analysis
Prokopidis K, Moriarty F, Bahat G, McLean J
Published in Journal of Cachexia, Sarcopenia and Muscle
Methodology
Random-effects meta-analysis of randomized controlled trials comparing NR or NMN vs placebo in adults with mean age 60.9-83 years, assessing skeletal muscle index, handgrip strength and gait speed, with narrative synthesis of other functional tests.
Key Findings
NMN supplementation showed no significant effect on skeletal muscle index; no consistent benefit of NR or NMN on muscle mass or physical function in older adults.
Conclusions
Current evidence does not support NMN and NR supplementation for preserving muscle mass and function in adults with mean age over 60 years.
Limitations
Small number of trials per outcome, heterogeneous dosing and durations, short follow-up.
Supplements Studied
Current evidence does not support NMN and NR supplementation for preserving muscle mass and function in adults with mean age of over 60 years.
Current evidence does not support NMN and NR supplementation for preserving muscle mass and function in adults with mean age of over 60 years.
Current evidence does not support NMN and NR supplementation for preserving muscle mass and function in adults with mean age of over 60 years.
Outcomes Measured
Current evidence does not support NMN and NR supplementation for preserving muscle mass and function in adults with mean age of over 60 years.
Study Details
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Disclosures
Funding
Not reported
This information is for educational purposes only. Always consult a healthcare professional before starting any supplement regimen.