Improvement in inner retinal function in glaucoma with nicotinamide (vitamin B3) supplementation: A crossover randomized clinical trial
Hui F, Tang J, Williams PA, McGuinness MB, Martin KR, Crowston JG
Published in Clinical and Experimental Ophthalmology
Methodology
Double-masked placebo-controlled crossover RCT of high-dose oral nicotinamide added to standard IOP-lowering treatment in established glaucoma
Key Findings
Oral nicotinamide produced a small but significant improvement in inner retinal function on electroretinography versus placebo, without change in intraocular pressure
Conclusions
Short-term high-dose nicotinamide improves inner retinal function in glaucoma, supporting further neuroprotection research
Limitations
Short duration; electrophysiological rather than visual field endpoints; single centre
Supplements Studied
Oral nicotinamide produced a small but significant improvement in inner retinal function on electroretinography versus placebo, without change in intraocular pressure
Related Health Concerns
Study Details
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Disclosures
Funding
National Health and Medical Research Council (Australia)
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