Citicoline (CDP-choline) for cognitive and behavioural disturbances associated with chronic cerebral disorders in the elderly (Cochrane Review)
Fioravanti M, Yanagi M
Published in Cochrane Database of Systematic Reviews
Methodology
Cochrane systematic review and meta-analysis of randomized placebo-controlled trials of CDP-choline in older adults with cognitive impairment of vascular or degenerative origin.
Key Findings
CDP-choline showed a modest positive effect on memory and behaviour, with some benefit on global clinical impression, over short to medium-term follow-up.
Conclusions
There is some evidence that CDP-choline has a positive effect on memory and behaviour in older people with mild-to-moderate cognitive impairment, but trials were short and heterogeneous.
Limitations
Included trials were mostly short, small and older; heterogeneity in diagnostic criteria and outcome instruments; no long-term data.
Supplements Studied
There is some evidence that CDP-choline has a positive effect on memory and behaviour in older people with mild-to-moderate cognitive impairment.
Outcomes Measured
CDP-choline has a positive effect on memory and behaviour in older people with mild-to-moderate cognitive impairment.
Related Health Concerns
Study Details
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Disclosures
Funding
Cochrane (no commercial funding)
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