The Role and Molecular Mechanism of D-Aspartic Acid in the Release and Synthesis of LH and Testosterone in Humans and Rats
Topo E, Soricelli A, D'Aniello A, Ronsini S, D'Aniello G
Published in Reproductive Biology and Endocrinology
Methodology
Twelve-day placebo-controlled trial of sodium D-aspartate 3.12 g/day in 23 men, with parallel rat mechanistic experiments.
Key Findings
Serum LH and testosterone rose significantly (about 33% for testosterone) in 20 of 23 treated men, with mechanistic data suggesting increased hypothalamic GnRH and testicular steroidogenesis.
Conclusions
D-aspartic acid acutely raised testosterone in untrained men in this initial trial.
Limitations
Very short duration; untrained sedentary men; small sample; findings not replicated in later trials.
Supplements Studied
Serum LH and testosterone rose significantly in 20 of 23 treated men over 12 days.
Outcomes Measured
Serum LH and testosterone rose significantly in 20 of 23 treated men over 12 days.
Study Details
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