Coenzyme Q10 in cardiovascular disease
Littarru, G.P., Tiano, L.
Published in BioFactors
Abstract
Clinical review of CoQ10 supplementation in cardiovascular disease treatment
Methodology
Narrative review of biochemical, mechanistic and clinical trial literature on coenzyme Q10 in cardiovascular disease (not a systematic review).
Key Findings
Narrative review summarising evidence that myocardial coenzyme Q10 is depleted in heart failure and lowered by statin therapy, and that supplementation (typically 100-300 mg/day) raises plasma CoQ10 and improves endothelial function and, in several small trials, functional class in chronic heart failure; effects on hard cardiovascular endpoints were unproven at the time of writing.
Conclusions
Coenzyme Q10 has a plausible bioenergetic and antioxidant rationale in cardiovascular disease, with supportive but not definitive clinical trial evidence, particularly in chronic heart failure and statin-treated patients.
Limitations
Narrative (non-systematic) review with no formal search strategy, pooled estimates or risk-of-bias appraisal; selective citation possible; predates the Q-SYMBIO trial; authors are long-standing CoQ10 researchers with field-specific interests.
Supplements Studied
Coenzyme Q10 in cardiovascular disease.
Outcomes Measured
Narrative review summarising evidence that myocardial coenzyme Q10 is depleted in heart failure and lowered by statin therapy, and that supplementation (typically 100-300 mg/day) raises plasma CoQ10 and improves endothelial function and, in several small trials, functional class in chronic heart failure; effects on hard cardiovascular endpoints were unproven at the time of writing.
Narrative review summarising evidence that myocardial coenzyme Q10 is depleted in heart failure and lowered by statin therapy, and that supplementation (typically 100-300 mg/day) raises plasma CoQ10 and improves endothelial function and, in several small trials, functional class in chronic heart failure; effects on hard cardiovascular endpoints were unproven at the time of writing.
Related Health Concerns
Study Details
Access Study
Disclosures
Funding
Academic institutional support
This information is for educational purposes only. Always consult a healthcare professional before starting any supplement regimen.