Effects of NAD+ precursor supplementation on glucose and lipid metabolism in humans: a meta-analysis
Zhong O, Wang J, Tan Y, Lei X
Published in Nutrition & Metabolism
Methodology
Meta-analysis of 40 clinical studies of NAD+ precursors (nicotinamide riboside, nicotinamide mononucleotide, nicotinic acid, nicotinamide) evaluating triglycerides, total cholesterol, LDL, HDL and fasting glucose.
Key Findings
Effects on lipid and glucose parameters were driven largely by nicotinic acid; newer precursors (NR, NMN) contributed limited metabolic change.
Conclusions
NAD+ precursor supplementation influences lipid metabolism, but effects differ substantially by precursor type.
Limitations
Pooling of chemically distinct precursors, heterogeneous populations and dose ranges, dominance of older nicotinic acid trials.
Supplements Studied
The main research terms of NAD+ precursors were Nicotinamide Riboside (NR), Nicotinamide Mononucleotide (NMN), Nicotinic Acid (NA), Nicotinamide (NAM).
The main research terms of NAD+ precursors were Nicotinamide Riboside (NR), Nicotinamide Mononucleotide (NMN), Nicotinic Acid (NA), Nicotinamide (NAM).
The main research terms of NAD+ precursors were Nicotinamide Riboside (NR), Nicotinamide Mononucleotide (NMN), Nicotinic Acid (NA), Nicotinamide (NAM).
Outcomes Measured
The main research terms of NAD+ precursors were Nicotinamide Riboside (NR), Nicotinamide Mononucleotide (NMN), Nicotinic Acid (NA), Nicotinamide (NAM).
Study Details
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Disclosures
Funding
Not reported
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