rct
    2025
    High Quality

    Investigation of the Influence of a Bitter Melon Product on Indicators of Cardiometabolic Health in Adults with Prediabetes

    Guarneiri LL, Wilcox ML, Kuan CM, Maki KC

    Published in Journal of the American Nutrition Association

    Methodology

    12-week randomized, parallel, placebo-controlled trial of low-dose (300 mg/day) and high-dose (600 mg/day) bitter melon extract in adults with prediabetes.

    Key Findings

    Both bitter melon groups showed smaller increases in blood glucose at 12 weeks than control (p < 0.05); a subgroup of older participants had greater HbA1c reduction on high dose.

    Conclusions

    Bitter melon extract may help maintain healthy glucose levels in prediabetes, mainly by limiting glucose rise rather than lowering it.

    Limitations

    Control group glucose rose markedly; HbA1c benefit limited to a subgroup analysis; industry involvement likely.

    Supplements Studied

    The bitter melon extract may help maintain a healthy level of glucose in adults with prediabetes.

    Outcomes Measured

    The bitter melon extract may help maintain a healthy level of glucose in adults with prediabetes.

    Related Health Concerns

    Study Details

    Year:2025
    Sample Size:75
    Duration:12 weeks
    Quality Score:7/10

    Disclosures

    Funding

    Not reported

    This information is for educational purposes only. Always consult a healthcare professional before starting any supplement regimen.