rct
    2011
    High Quality

    Vitamin E and the risk of prostate cancer: the Selenium and Vitamin E Cancer Prevention Trial (SELECT)

    Klein EA, et al

    Published in JAMA

    Key Findings

    Vitamin E supplementation significantly increased prostate cancer incidence versus placebo; selenium provided no benefit.

    Conclusions

    Vitamin E supplementation increased prostate cancer risk in healthy men.

    Limitations

    Single cancer endpoint; healthy male population.

    Supplements Studied

    Selenium
    Mineral

    Selenium supplementation showed no benefit on prostate cancer risk compared with placebo.

    Vitamin E
    Vitamin

    Dietary supplementation with vitamin E significantly increased the risk of prostate cancer among healthy men.

    Outcomes Measured

    Cancer Survival Rate

    Dietary supplementation with vitamin E significantly increased the risk of prostate cancer among healthy men.

    Tumor Response Rate

    Vitamin E supplementation significantly increased prostate cancer risk by 17%, and selenium provided no protective benefit

    UV Protection

    Vitamin E supplementation significantly increased prostate cancer risk by 17%

    Related Health Concerns

    Cancer
    Prostate Cancer

    Study Details

    Year:2011
    Sample Size:35,533
    Duration:364 weeks
    Quality Score:9/10

    Access Study

    View on DOIView on PubMedOriginal Source

    This information is for educational purposes only. Always consult a healthcare professional before starting any supplement regimen.