Drinking Water to Prevent Postvaccination Presyncope in Adolescents: A Randomized Trial
Kemper AR, et al
Published in Pediatrics
Methodology
Pragmatic randomised controlled trial in adolescents aged 11-21 attending vaccination visits, randomised to offered water (500 mL, 10-60 min pre-vaccination) versus usual care; presyncope measured by validated symptom scale.
Key Findings
In 1,807 adolescents receiving vaccinations, drinking 500 mL of water 10-60 minutes beforehand did not reduce presyncope (fainting-related symptoms): rates were similar between the water and no-water groups, and syncope itself was rare in both arms.
Conclusions
Drinking water before vaccination did not prevent postvaccination presyncope.
Limitations
Single health-system setting; presyncope assessed by symptom checklist rather than objective haemodynamics; actual volume consumed and timing varied; underpowered for frank syncope.
Related Health Concerns
Study Details
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Disclosures
Funding
US Centers for Disease Control and Prevention / academic institutional support
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