Treatment of edema and increased capillary filtration in venous hypertension with total triterpenic fraction of Centella asiatica: a placebo-controlled, randomized, dose-ranging trial
De Sanctis MT, Belcaro G, Incandela L, Cesarone MR, Griffin M, Ippolito E, Cacchio M
Published in Angiology
Methodology
Randomised, placebo-controlled, dose-ranging trial of total triterpenic fraction of Centella asiatica 60 mg or 30 mg twice daily for 8 weeks in venous hypertension
Key Findings
Both doses reduced ankle oedema and capillary filtration rate, with a clear dose-response versus placebo.
Conclusions
Standardised Centella extract reduces objective microcirculatory and oedema measures in venous hypertension.
Limitations
Small single-centre trial; surrogate microcirculatory endpoints.
Supplements Studied
Total triterpenic fraction of Centella asiatica reduced ankle oedema and capillary filtration rate in a dose-dependent manner versus placebo.
Related Health Concerns
Study Details
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