Effects of selected dietary supplements on migraine prophylaxis: A systematic review and dose-response meta-analysis of randomized controlled trials
Talandashti MK, Shahinfar H, Delgarm P, Jazayeri S
Published in Neurological Sciences
Methodology
Systematic review and dose-response meta-analysis of 22 randomized controlled trials of dietary supplements for migraine prophylaxis; certainty rated with GRADE.
Key Findings
Magnesium reduced attacks (MD -2.51), severity (MD -0.88) and monthly migraine days (MD -1.66); CoQ10 reduced frequency (-1.73), severity (-1.35) and duration (-1.72); riboflavin reduced frequency (-1.34); alpha-lipoic acid, probiotics and vitamin D also reduced frequency, while omega-3 showed no significant reduction.
Conclusions
Several supplements — magnesium, CoQ10, riboflavin, vitamin D, probiotics and alpha-lipoic acid — modestly reduce migraine frequency, but effects on other outcomes were inconsistent and omega-3 was not effective.
Limitations
Heterogeneous trials, many small and at risk of bias, variable doses and outcome definitions, low-to-moderate GRADE certainty.
Supplements Studied
Magnesium supplementation reduced migraine attacks (mean difference (MD) = -2.51), severity (MD = -0.88), and the monthly migraine days (MD = -1.66) compared with the control group.
Magnesium supplementation reduced migraine attacks (mean difference (MD) = -2.51), severity (MD = -0.88), and the monthly migraine days (MD = -1.66) compared with the control group.
Magnesium supplementation reduced migraine attacks (mean difference (MD) = -2.51), severity (MD = -0.88), and the monthly migraine days (MD = -1.66) compared with the control group.
Magnesium supplementation reduced migraine attacks (mean difference (MD) = -2.51), severity (MD = -0.88), and the monthly migraine days (MD = -1.66) compared with the control group.
Magnesium supplementation reduced migraine attacks (mean difference (MD) = -2.51), severity (MD = -0.88), and the monthly migraine days (MD = -1.66) compared with the control group.
Magnesium supplementation reduced migraine attacks (mean difference (MD) = -2.51), severity (MD = -0.88), and the monthly migraine days (MD = -1.66) compared with the control group.
Related Health Concerns
Study Details
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Disclosures
Funding
Not stated
This information is for educational purposes only. Always consult a healthcare professional before starting any supplement regimen.