A randomized, placebo-controlled, clinical trial of high-dose supplementation with vitamins C and E, beta carotene, and zinc for age-related macular degeneration and vision loss: AREDS report no. 8
Age-Related Eye Disease Study Research Group
Published in Archives of Ophthalmology
Methodology
Multicentre randomised placebo-controlled trial of antioxidants including beta carotene plus zinc in 3,640 participants followed a median 6.3 years.
Key Findings
The antioxidant plus zinc formulation reduced progression to advanced age-related macular degeneration by about 25% in higher-risk participants.
Conclusions
High-dose antioxidant plus zinc supplementation slows progression of intermediate age-related macular degeneration.
Limitations
Beta carotene component later removed due to lung cancer risk in smokers; no benefit in early disease.
Supplements Studied
Antioxidants plus zinc reduced progression to advanced age-related macular degeneration by about 25% in higher-risk participants.
Antioxidants plus zinc reduced progression to advanced age-related macular degeneration by about 25% in higher-risk participants.
Outcomes Measured
Antioxidant plus zinc supplementation reduced progression to advanced macular degeneration and vision loss.
Related Health Concerns
Study Details
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This information is for educational purposes only. Always consult a healthcare professional before starting any supplement regimen.