Differences in Metabolite Profiles of Dihydroberberine and Micellar Berberine in Caco-2 Cells and Humans - A Pilot Study
Kwon M, Roh YS, Kuo YC
Published in International Journal of Molecular Sciences
Methodology
Pilot pharmacokinetic comparison of dihydroberberine and micellar berberine in Caco-2 monolayers and in healthy human volunteers.
Key Findings
Both delivery forms increased systemic berberine exposure relative to standard berberine, with differing metabolite profiles; dihydroberberine yielded higher berberine and reduced-metabolite concentrations.
Conclusions
Delivery form substantially changes berberine pharmacokinetics; clinical outcome data for dihydroberberine remain absent.
Limitations
Pharmacokinetic endpoints only; very small sample; industry-affiliated authors.
Supplements Studied
Dihydroberberine yielded higher berberine and reduced-metabolite concentrations than micellar berberine.
Both delivery forms increased systemic berberine exposure relative to standard berberine, with differing metabolite profiles; dihydroberberine yielded higher berberine and reduced-metabolite concentrations.
Study Details
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