Effects of Nicotinamide Mononucleotide Supplementation on Muscle and Liver Functions Among the Middle-aged and Elderly: A Systematic Review and Meta-analysis of Randomized Controlled Trials
Wang JP, Wang L, Wang T, Zhang YD
Published in Current Pharmaceutical Biotechnology
Methodology
Systematic review and meta-analysis of 9 randomized controlled trials of NMN in middle-aged and elderly participants, quality assessed with the Cochrane Handbook.
Key Findings
NMN improved gait speed (SMD 0.34, 95% CI 0.03-0.66, p=0.033) and ALT (SMD -0.29, 95% CI -0.55 to -0.03, p=0.028); lower doses showed the most prominent effects.
Conclusions
NMN may modestly improve some muscle and liver function markers in middle-aged and elderly adults, but effects are small and inconsistent across outcomes.
Limitations
Few trials, small samples, short durations, and inconsistency with other meta-analyses reporting null muscle effects.
Supplements Studied
Based on changes in gait speed (SMD: 0.34 m/s, 95%CI [0.03, 0.66] p = 0.033), NMN had significant effects on muscle mass.
Based on changes in gait speed (SMD: 0.34 m/s, 95%CI [0.03, 0.66] p = 0.033), NMN had significant effects on muscle mass.
Based on changes in gait speed (SMD: 0.34 m/s, 95%CI [0.03, 0.66] p = 0.033), NMN had significant effects on muscle mass.
Outcomes Measured
Based on changes in gait speed (SMD: 0.34 m/s, 95%CI [0.03, 0.66] p = 0.033), NMN had significant effects on muscle mass.
Study Details
Access Study
Disclosures
Funding
Not reported
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