Effect of Selenium and Vitamin E on Risk of Prostate Cancer and Other Cancers: The Selenium and Vitamin E Cancer Prevention Trial (SELECT)
Lippman SM, Klein EA, Goodman PJ, Lucia MS, Thompson IM, Ford LG, Parnes HL, Minasian LM, Gaziano JM, Hartline JA, Parsons JK, Bearden JD, Crawford ED, Goodman GE, Claudio J, Winquist E, Cook ED, Karp DD, Walther P, Lieber MM, Kristal AR, Darke AK, Arnold KB, Ganz PA, Santella RM, Albanes D, Taylor PR, Probstfield JL, Jagpal TJ, Crowley JJ, Meyskens FL, Baker LH, Coltman CA
Published in JAMA
Key Findings
Selenium 200 mcg/day did not prevent prostate cancer, and a non-significant increase in type 2 diabetes risk was observed in the selenium arm.
Conclusions
Selenium supplementation offers no cancer prevention benefit in selenium-replete men.
Limitations
Participants were largely selenium-replete at baseline; single selenomethionine form.
Supplements Studied
Selenium 200 mcg/day did not prevent prostate cancer, and a non-significant increase in type 2 diabetes risk was observed in the selenium arm.
Selenium 200 mcg/day did not prevent prostate cancer, and a non-significant increase in type 2 diabetes risk was observed in the selenium arm.
Outcomes Measured
Selenium did not prevent prostate cancer in selenium-replete men.
Related Health Concerns
Study Details
Access Study
This information is for educational purposes only. Always consult a healthcare professional before starting any supplement regimen.