Probiotics and secretory IgA in mucosal immunity: a systematic review and meta-analysis of randomized trials
Zhang H, Yeh C, Jin Z, Ding L, Liu BY, Zhang L
Published in Synthetic and Systems Biotechnology
Methodology
Meta-analysis of randomized controlled trials of probiotic supplementation reporting salivary or intestinal secretory IgA and mucosal infection outcomes.
Key Findings
Probiotics significantly increased secretory IgA concentrations and reduced respiratory and gastrointestinal infection incidence.
Conclusions
Probiotics strengthen mucosal antibody defence at gut and airway surfaces.
Limitations
Strain-specific effects; heterogeneity in IgA sampling methods.
Supplements Studied
Probiotics significantly increased secretory IgA concentrations and reduced infection incidence
Outcomes Measured
Probiotics significantly increased secretory IgA concentrations and reduced respiratory and gastrointestinal infection incidence
Study Details
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