Pancreatic enzyme replacement therapy in chronic pancreatitis: a systematic review and meta-analysis
de la Iglesia-Garcia D, Huang W, Szatmary P, Baston-Rey I, Gonzalez-Lopez J, Prada-Ramallal G
Published in Gut
Methodology
Meta-analysis of randomized trials of pancreatic enzyme replacement therapy on fat absorption, symptoms and nutritional status in chronic pancreatitis.
Key Findings
Enzyme replacement significantly improved coefficient of fat absorption and nutritional markers versus placebo or no treatment.
Conclusions
Exogenous pancreatic enzymes reliably restore fat digestion in exocrine insufficiency.
Limitations
Trials short and heterogeneous in enzyme dosing.
Supplements Studied
Enzyme replacement significantly improved coefficient of fat absorption and nutritional markers
Outcomes Measured
Enzyme replacement significantly improved coefficient of fat absorption and nutritional markers versus placebo or no treatment
Related Health Concerns
Study Details
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