Oral hyaluronan relieves wrinkles: a double-blinded, placebo-controlled study over a 12-week period
Oe M, Sakai S, Yoshida H, Okado N, Kaneda H, Masuda Y, Urushibata O
Published in Clinical, Cosmetic and Investigational Dermatology
Methodology
Twelve-week randomised double-blind placebo-controlled trial of oral hyaluronan 120 mg daily at two molecular weights in adults with crow's feet wrinkles
Key Findings
Both molecular weights significantly reduced wrinkle depth and improved skin lustre and suppleness compared with placebo.
Conclusions
Oral hyaluronan of high and low molecular weight both reduce facial wrinkles over 12 weeks.
Limitations
Small sample; manufacturer sponsored; Japanese cohort only.
Supplements Studied
Both molecular weights significantly reduced wrinkle depth and improved skin lustre and suppleness compared with placebo.
Outcomes Measured
Both molecular weights significantly reduced wrinkle depth compared with placebo.
Skin luster and suppleness improved significantly and wrinkle depth decreased in the hyaluronan group versus placebo
Study Details
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