Probiotics for autism spectrum disorder: An updated systematic review and meta-analysis of effects on symptoms
Soleimanpour S, Abavisani M, Khoshrou A, Sahebkar A
Published in Journal of Psychiatric Research
Methodology
PRISMA-guided systematic review and random-effects meta-analysis of randomized clinical trials of probiotic interventions on ASD behavioural symptoms; risk of bias assessed with Cochrane RoB 2.
Key Findings
Probiotic interventions were associated with modest improvements in behavioural symptom scores in some trials, with substantial heterogeneity across studies and formulations.
Conclusions
Probiotics show preliminary promise for behavioural symptoms in ASD but the evidence base remains heterogeneous and inconclusive.
Limitations
Heterogeneous strains, doses and outcome measures; small trials; short follow-up.
Supplements Studied
Alterations in the gut microbiota may correlate with the severity of ASD symptoms.
Related Health Concerns
Study Details
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Disclosures
Funding
Not specified
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