systematic_review
    2026

    Preparation, bioactivities, structure-activity relationships, applications, and safety concerns of Inonotus obliquus polysaccharides: A review

    Cui M, Wang X, Yu T, Ma H, Xin J

    Published in International Journal of Biological Macromolecules

    Methodology

    Review of extraction, structural characterisation, bioactivity and safety data for Inonotus obliquus polysaccharides

    Key Findings

    Immunomodulatory, antioxidant and gut-organ-axis activities of the beta-glucan-rich polysaccharides depend strongly on molecular weight, linkage pattern and triple-helix integrity.

    Conclusions

    Standardised preparation is needed before biological effects can be compared or translated to humans.

    Limitations

    No human efficacy data; heterogeneous extraction methods limit inter-study comparability.

    Supplements Studied

    Chaga
    Herb

    Inonotus obliquus polysaccharides (IOPs) are beta-glucan-rich heteropolysaccharides whose structural diversity underlies their immunomodulatory, antioxidant, and gut-organ-axis-mediated activities.

    Outcomes Measured

    Inonotus obliquus polysaccharides (IOPs) are beta-glucan-rich heteropolysaccharides whose structural diversity underlies their immunomodulatory, antioxidant, and gut-organ-axis-mediated activities.

    Study Details

    Year:2026
    Quality Score:5/10

    Disclosures

    Funding

    Not reported

    This information is for educational purposes only. Always consult a healthcare professional before starting any supplement regimen.